In our study, the data showed that the scores of cognitive performance and fatigue were positively correlated with reductions in the serum levels of both nitric oxide (NO) and adiponectin and negatively correlated with reduced or sedentary physical activity, VO2 max, obesity, and diabetes (HbA1c (%), insulin). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.