Taken together, at the transcription level, YM155 could inhibit the expression of BIRC5 (encoding survivin protein) and reduce the production of survivin mRNA; at the protein level, TmSm protein was delivered to the cytoplasm through TAT peptide and formed a heterodimer with wild‐type survivin, competitively inhibits the formation of survivin homodimer, thereby promoting the expression of caspase‐3, and ultimately leading to cancer cell apoptosis. Here, BIRC5 is linked to cancer.