When protein and YM155 were added to NCs at a feed molar ratio of 1:10, the YM155/NP molar ratios in FTH1/YM155 NCs and FTS/YM155 NCs were 1.6 and 1.8, respectively (Figure S5c); these formulations had similar cytotoxicity to cancer cells (Figure S5d). This evidence concerns the gene FTH1 and cancer.