In addition, the expression of M2 markers (Arg1, CD206, and Ym1) was markedly elevated in BLM‐treated mice, BLM + liposomes‐treated mice and BLM + Scr siRNA‐loaded liposomes‐treated mice, whereas in Mecp2 siRNA‐loaded liposomes‐treated mice, a substantial reduction in M2 markers was detected (Figure 6b). The gene discussed is ARG1; the disease is Bloom syndrome.