FOS and central core myopathy: As in the CCO studies, results are controversial: several research studies have achieved an increase of c-Fos protein expression but others found a decrease of its expression in several brain areas in healthy and disease models (Nadur-Andrade et al., 2016; De Taboada and Hamblin, 2019; Arias et al., 2020; Li et al., 2021; Table 1).