ADRA2A and diabetic retinopathy: Replication of the top variants in the HKDR conferred significantly increased risk of ADRA2A rs10885122 for advanced diabetic retinopathy in persons with type 2 diabetes who were born during famine, while no risk was observed in unexposed individuals (OR, 95% CI, 3.13, 1.12–13.2, pfamine = 0.026 vs. 0.94, 0.18–17.4, pnon famine = 0.953) (Table 2).