Notably, expression level of the ADRA2A and PROX1 genes did not significantly differ in the retinas from non-famine type 2 diabetes patients with mild non-proliferative DR and non-diabetic donors (Blood and Tissue Bank of Vall d’Hebron University Hospital) (Supplementary Table 4), ruling out the impact of diabetes condition per se on expression level of identified genetic variants in the human retina. This evidence concerns the gene ADRA2A and diabetes mellitus.