LRRK2 and Parkinson disease: LRRK2 gene mutations implicated in PD commonly increase kinase activity (Dächsel and Farrer, 2010); consequently, molecules that are neuroprotective from aberrant LRRK2 activity are sought for both familial LRRK2-mutant forms of PD and for other forms that may be characterized by elevated kinase activity (Bloem et al., 2021).