Yan et al. (2021) revealed higher regional homogeneity (ReHo) values in SFGmed in MDD patients, Zheng et al. (2020) revealed stronger FC between the left amygdala and bilateral ACC/SFGmed, along with higher levels of interleukin-6 and anxiety in patients with end stage renal disease (Bacteroides mainly). Here, IL6 is linked to major depressive disorder.