Many of the upregulated genes in nicotine-treated sperm are known to be involved in asthma pathogenesis, including L-Histidine decarboxylase (Hdc), Fc receptor-like 3 (Fcrl3), Endothelin receptor type B (Ednrb), and Complement C4A (C4a). The gene discussed is EDNRB; the disease is asthma.