Those target genes included those previously implicated in asthma pathogenesis, such as ADAM metallopeptidase domain 33 (Adam33), PHD finger protein 11 (Phf11), Dipeptidyl peptidase like 10 (Dpp10), Interleukin 4 (Il4), Brain-derived neurotrophic factor (Bdnf), Serine peptidase inhibitor, Kazal type 5 (Spink5), Cd69 molecule (Cd69), etc. Following linkage studies, Adam33 (70), Phf11 (71) and Dpp10 (72) have been identified to be associated with asthma and asthma-related phenotypes. Here, IL4 is linked to asthma.