Another component that modulates TNFα-induced remodeling is the erythropoietin-producing human hepatocellular receptor (EphA), which is a receptor tyrosine kinase that mediates cell-adhesion and leukocyte homing in atherosclerosis by promoting ICAM1 and VCAM1 expression on ECs (181). The gene discussed is ICAM1; the disease is atherosclerosis.