Cell-specific effects of the IL-1β antibody (mouse monoclonal antibody, Novartis, 10 mg/kg) were tested by Gomez et al. on VSMC lineage tracing Apoe−/− mice where the fate and migration of SMCs can be monitored during the development of atherosclerosis by using an inducible Cre-flox system to label MYH11+ SMC specific YFP expression (Apoe−/−Myh11-CreERT2R26R-YFP). Here, APOE is linked to atherosclerosis.