The chemokine CXCL12 (Table 1) is highly expressed in human atherosclerotic lesions (32, 67) and genome-wide association studies noted that the genomic locus 10q11, hosting the CXCL12 gene and the intergenic single nucleotide polymorphism (SNP) rs2802492 located near CXCL12, are independently associated with CXCL12 plasma levels and coronary artery disease (CAD) risk (68, 69). This evidence concerns the gene CXCL12 and coronary artery disorder.