Although this group could show that also the GPVI- and α2β1 integrin-agonist collagen induces platelet FXa-generation in the presence of plasma, the inhibitory effect of low-dose rivaroxaban on collagen-induced P-selectin surface expression was not significant compared to platelets from patients with atrial fibrillation prior rivaroxaban treatment. Here, GP6 is linked to atrial fibrillation.