TF and peripheral arterial disease: The good platelet responsiveness to clopidogrel of the majority of our patients with PAD is also reflected by group comparisons demonstrating pronounced reduction of integrin αIIbβ3 activation and α-/δ-granule release in response to the ADP-sensitive agonists, namely, thrombin, TRAP-6, and convulxin (39, 40) as well as of the peak of platelet-dependent thrombin generation triggered by TF (36) and thrombin (19).