However, platelets from patients with PAD under ASA plus clopidogrel therapy showed lower platelet activation in vivo, expressed by a lower surface presentation of integrin αIIbβ3 (Figure 5A) and P-selectin (Figure 5B) and by higher uptake of the selective ADP/ATP binding dye mepacrine into the δ-granules (Figure 5C). Here, SELP is linked to peripheral arterial disease.