<h4>Objective</h4>We report a 3-generation family with <i>SCN5A</i> c.611 C>A rare variant, whose clinical characteristics are dilated cardiomyopathy (DCM) combined with multifocal ectopic Purkinje-related premature contractions (MEPPC). Here, SCN5A is linked to familial dilated cardiomyopathy.