The frailty group was older, had higher BMI, SBP, heart rate, serum creatinine, urine albumin-creatinine ratio (uACR), and HDL cholesterol levels, were more likely to be smokers, were more likely to be black, were more likely to use statins and aspirin, had higher rates of CVD and CKD, had higher rates of self-reported diabetes, stroke, or TIA, and anemia compared with the fit group and less fit group. The gene discussed is ALB; the disease is Stroke.