CDKN2B and neoplasm: In addition to SNV/Indels, copy number variations (CNVs) were found in five genes, consisting of copy number gains in ERBB2 and YAP1 and copy number losses in CDKN2A, CDKN2B, and PDPK1. Three variations were successfully verified by FISH experiment performed on tumor tissue specimens (ERBB2, CDKN2A/2B; Figure 4C).