Expression data shown in Figure 6A is relative to the average expression (Z-score) of each gene across all other groups of medulloblastoma samples (SHH group Clusters from (32) In cluster 2, where REST expression is elevated, and the tumors are more immature, a number of patients tumors consistently expressed G9A and KDM7A at levels higher or lower than the Z-score (Figure 6A). The gene discussed is REST; the disease is medulloblastoma.