Further, GPR56 is also implicated in neuronal myelination and myelin repair (15, 16), Oligodendrocyte precursor cell (OPC) proliferation (17), radial axonal sorting by Schwann cells (16), and others. Altered expression of GPR56 has been reported in multiple cancers, including glioblastoma, melanoma, breast cancer, and colon cancer (18–22). This evidence concerns the gene ADGRG1 and colonic neoplasm.