GPR56 silencing in GBM cell line U373 increased their invasive, migratory behavior (Figures 2B, C) as well as resulted in changes in gene, protein, and phosphoprotein expression, mapping to pathways and processes which are consistent with the mesenchymal state (Figures 3 and 4; Table 3). This evidence concerns the gene ADGRG1 and glioblastoma.