Furthermore, Xing M demonstrated that activation of MAPK signaling pathway resulted in upregulation of tumor-promoting genes (e.g. VEGFA, MET, HIF1A, UPA, UPAR, TGFB1, and TSP1) as well as downregulation of tumor suppression and thyroid genes (e.g. TIMP3, SLC5A8, DAPK1, NIS, TSHR, and TPO) (2). This evidence concerns the gene TPO and neoplasm.