PODXL and neoplasm: A priori, this alleviates concerns regarding toxicity of this Ab on normal healthy tissue expressing Podxl and this is further supported by our data showing that PODO447-ADC fails to exhibit any substantial toxicity against normal HUVECs or against human cell lines where the Podxl gene has been inactivated, while simultaneously exhibiting dose-dependent killing of a broad spectrum of Podxl-positive tumor targets at clinically relevant concentrations in vitro.