We explored the carcinogenic role of SOCS3 in several types of cancer through mRNA and protein expression level analysis and found that SOCS3 was upregulated or downregulated in almost all tumor types, and in a variety of tumors, its expression was related with the tumor stage and/or histological subtype, such as BLCA, THCA, and MESO. The gene discussed is SOCS3; the disease is cancer.