Using GEPIA database, we observed that upregulation of SOCS3 expression was relevant to poor overall survival rate in GBM (p=0.03), KIRC (p=0.00013), LGG (p=2.8e−5), STAD (p=0.0067), and UVM (p=0.037), whereas BRCA (p=0.0077) patients with high SOCS3 expression had higher overall survival rate (Figure 6A). Here, SOCS3 is linked to glioblastoma.