We assessed tumor immune infiltration from 39 TCGA cancers, and seven of these exhibited a notable positive relationship between SOCS3 expression levels and infiltration of six kinds of immune cells (B cells, CD8 + T cells, CD4 + T cells, DCs macrophages, and neutrophils), including CHOL, LGG, LIHC PAAD, PRAD, SKCM, and STAD. The gene discussed is CD4; the disease is cancer.