We found that the staining of SOCS3 in the kidneys, ovaries, uterus, colon and rectum, and brain tumor specimens were higher than that in the normal tissues, which was consistent with the results of mRNA expression analysis, suggesting that high SOCS3 expression may be a risk factor for LGG, GBM, COAD, KIRC, OV, and UCS (Figure 5A). This evidence concerns the gene SOCS3 and brain neoplasm.