The results indicated that SOCS expression was lower in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), kidney chromophobe (KICH), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), testicular germ cell tumors (TGCT) (p<0.001), uterine corpus endometrial carcinoma (UCEC) (p<0.01) and head and neck squamous cell carcinoma (HNSC), and kidney renal papillary cell carcinoma (KIRP) (p<0.05) compared with the healthy controls. The gene discussed is CISH; the disease is invasive breast carcinoma.