PTBP1 and cancer: To examine whether PTBP1 was an independent prognostic factor in cancers, Univariate Cox regression analysis demonstrated that PTBP1expression (p < 0.001), pathological stage (p < 0.001), T stage (p < 0.001), N stage (p < 0.001), and M stage (p = 0.006) were significantly correlated with OS in LUAD (Figure 8H); Multivariate analysis indicated that PTBP1 expression (p = 0.011), and T stage (p =0.016) were significantly correlated with OS in LUAD (Figure 8I); These results confirmed that PTBP1 was an independent risk factor for LUAD patients lead to adverse clinical outcomes.