Molecular characterizations of UTUC, such as Ki-67, Her2, P16, P53, Uroplakin III, Microsatellite instability (MSI), Snail, E-Cadherin and PD-L1, have been shown to be associated with tumor behavior and oncological outcomes (5–10). The gene discussed is CD274; the disease is renal pelvis/ureter urothelial carcinoma.