Accordingly, in this study, we for the first time investigated the synergistic anti-tumorigenic effect of BBR and OPCs in CRC by enhancing cellular apoptosis and by downregulating the expression of MYB via the PI3K-Akt signaling pathway (Figure 7), using a series of systematic cell culture and patient-derived tumor organoid experimental models. Here, AKT1 is linked to colorectal carcinoma.