This analysis illustrated that CRIM1 expression was positively linked to CD8+ T-cells (r=0.297, p=9.47e-22), endothelial cells (r=0.392, p=8.87e-38) and neutrophils (r=0.498, p=2.31e-63), and negatively linked to NK (r=-0.204, p=8.50e-11), B-cells (r=-0.3, p=3.70e-22), CD4+ T-cells (r=-0.574, p=4.08e-88), tumor purity (r=-0.177, p=1.98e-08), macrophage M1(r=-0.318, p=8.21e-25), and Tregs (r=-0.266, p=1.53e-17) (Figure 6). The gene discussed is CD4; the disease is neoplasm.