BIRC5 and hepatocellular carcinoma: The JAK/STAT signaling pathway plays important roles in many cellular functions, including cell proliferation activated by the transcription CCND1, BIRC5 and Mcl-1 (143) and the repression of Hippo signaling in HCC pathogenesis via Hippo kinase (Mst1 and Mst2) also plays a role in the promotion of proliferation (144).