Using dynamic trend analysis, differential analysis, and predictive analysis, this study screened 10 genes with prognostic significance in gastric cancer (RXRG, AGT, BCHE, UBE2QL1, PLCXD3, ADCYAP1R1, NRCAM, MAMDC2, CDH19, and GAMT). This evidence concerns the gene MAMDC2 and gastric cancer.