Immunotherapy (IO), including anti-programmed cell death protein 1 (anti-PD1) and anti-cytotoxic T lymphocyte-associated protein 4 (anti-CTLA-4) therapies (5), and targeted therapy (TT) against BRAF V600 E/K mutations (BRAFi) and MEK/MAPK signaling pathways (MEKi) (6), have improved progression-free survival (PFS) and overall survival (OS) of patients with metastatic melanoma and reached median OS of up to 24.3 months (7). This evidence concerns the gene CTLA4 and metastatic melanoma.