ANGPT2 and pituitary tumor: In contrast, expression of ANGPT2 (3.6 x 103 copies/μg total RNA) and TEK (3.4 x 103) was significantly elevated in all types of pituitary tumors with an overall increase of 9.2 (p<0.0001) and 7.3-fold (p<0.0001), respectively (Figure 4A).