Here we show that loss of PINK1 reduces tumor cell growth in two different Ras-driven tumor models: Embryonic fibroblasts (MEFs) from PINK1-/- mice immortalized with SV40 large T and transduced with a RasG12D retrovirus, and patient-derived HCT116 human colon carcinoma cells expressing an endogenous RasG13D mutation with CRISPR-Cas9-introduced PINK1 gene deletions. This evidence concerns the gene LARGE1 and colon carcinoma.