Consistent with the observed increase in WNT related genes in tumor cells (Figures 4A, 5F), we saw high scores for WNT-related interactions (ligands Sfrp1 and Wnt5a and receptors Fzd6, Fzd7 and Lrp6) and significant BMP-related interactions (e.g. from Bmp4 with Bmpr1a). The gene discussed is LRP6; the disease is neoplasm.