In agreement with our previous work (Sacramento et al., 2017; Sacramento et al., 2018), CSN resection reversed insulin resistance and attenuated increased insulin secretion and glucose intolerance promoted by short-term hypercaloric diets, but also reversed the exacerbated dysmetabolic states induced by long-term HFHSu intake, without altering insulin secretion. The gene discussed is INS; the disease is Insulin resistance.