In accordance with Dos Santos et al. (2018), short-term HFHSu intake increased by 40% of the TH immunoreactivity, a marker for type I cells, which is concomitant with the increase in the CB size observed in prediabetes animal models (Ribeiro et al., 2013) and type 2 diabetes patients (Cramer et al., 2014), an effect that was restored by the CSN resection (Figure 4A). The gene discussed is TH; the disease is type 2 diabetes mellitus.