It was shown that the mutant form of IDH1/2 catalyzes the irreversible accumulation of 2-hydroxyglutaric acid (2HG), which is an alternative marker for IDH1 mutated intrahepatic cholangiocarcinoma [12], while 2HG produced by IDH1 mutations has been reported to promote erastin-induced ferroptosis in human fibroma cells and esophageal squamous carcinoma cells [13]. The gene discussed is IDH1; the disease is cholangiocarcinoma.