EA2 group present a significantly higher frequency of null mutation than the groups of epilepsy (P = 7.92 × 10–5), FHM1 (P = 2.85 × 10–5), SCA6 (P = 5.69 × 10–3), or CSVD (P = 3.77 × 10–6) (Figure 4A). This evidence concerns the gene CACNA1A and epilepsy.