TARDBP and amyotrophic lateral sclerosis: For instance, TDP43 has been reported as a biomarker for the frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and limbic-predominant age-related TDP-43 encephalopathy (LATE) (Steinacker et al., 2008; Majumder et al., 2018; Nelson et al., 2019).