Further, when the model included AD biomarkers Aβ and p-tau, and ER-signalosome parameters PC1 and PC2, predictability of MCI and SMC were 73.9 and 50.0%, respectively (LR χ2 = 40.66, p < 0.001); therefore, the slightly worse than in the absence of AD biomarkers. The gene discussed is MAPT; the disease is Alzheimer disease.