In this study, the expression of pro-caspase-1, cleaved caspase-1 p20, pro-IL-1β, cleaved IL-1β, and GSDMD in C57 mice after cerebral ischemia/reperfusion was significantly higher than those in Cas-1 ko mice in the same treatment group, suggesting that blocking the activation of caspase-1 can effectively inhibit the inflammatory response after cerebral ischemia/reperfusion. Here, IL1B is linked to brain ischemia.