NLRP3, as the initiating factor of aseptic inflammatory response of the central nervous system after cerebral ischemia, induces cell pyroptosis, resulting in nerve cell injury, and plays a key role in the inflammatory cascade effect after cerebral ischemia/reperfusion (Fann et al., 2013; Walsh and Muruve, 2014). The gene discussed is NLRP3; the disease is brain ischemia.