Relevant studies have shown that inhibiting the expression of caspase-1 can reduce the neuronal injury in the brain after cerebral ischemia/reperfusion and reduce the cerebral infarct area after cerebral ischemia/reperfusion, such as knocking out the caspase-1 gene in mice or using the caspase-1 inhibitor Ac-YVAD = CMK (Liu et al., 2018; Liang et al., 2021). Here, CASP1 is linked to Cerebral ischemia.