Both SAA and EGCG can bind to the viral RBD and host cell ACE2 receptor, which blocks viral infection.[17, 18] EGCG is also known to inhibit 3CLpro activity.[27] Our results indicate that SAA also directly targets 3CLpro and blocks its enzymatic activity, suggesting that these two compounds may inhibit SARS‐CoV‐2 infection in several ways by targeting the RBD, ACE2, and/or 3CLpro. The gene discussed is ACE2; the disease is viral infectious disease.