The Coronavirus spike protein (S)/ACE2 interaction is crucial for the SARS-CoV infections and after this interaction with SARS-CoV-2, ACE-2 is downregulated and, consequently, the AngII/AT1R axis is favored at the expense of Ang1-7/MasR axis, thus promoting the onset of the respiratory syndrome [12–15]. The gene discussed is ACE2; the disease is severe acute respiratory syndrome.