Collectively this evidence delineates a model in which autocrine or paracrine proinflammatory signaling sustain the activation of TAK-1/NF-κB cascade, and IL-8 appears to be the most significantly regulated factor by this intracellular pathway and one of the most significant candidates for selecting those patients with resectable pancreatic cancer more likely to benefit from preoperative chemotherapeutic regimens. This evidence concerns the gene MAP3K7 and familial pancreatic carcinoma.