Figure 5 shows a heatmap (made using Enrichr and Appyter) with the top KEGG pathways that were overrepresented in the IO&NS/Wnt network, namely, pathways of neurodegeneration, Wnt and NF-κB signaling, and peroxisome. Figure 6 shows a heatmap with the PANTHER 2016 pathways, which were overrepresented in the network, namely, Wnt, apoptosis, TLR and cadherin pathways, and the Alzheimer’s disease pre-senilin pathway. The gene discussed is NFKB1; the disease is Alzheimer disease.