In Huh7 and HCC‐LM3 modulated cells, the reduced SULT2A1 expression obviously increased the expression of p65 and p‐p65, and the upregulation of SULT2A1 reversed this alternation following 27‐OHC treatment (Figure 5A,B). This evidence concerns the gene SULT2A1 and hepatocellular carcinoma.