Previous, we found that the cell proliferation, migration, and invasion of Nasopharyngeal carcinoma (NPC) are all inhibited when Period 2 is overexpressed, as we observed in vitro and in vivo, and overexpression of PER2 has been shown to boost the chemotherapeutic effectiveness of a new nanosystem that includes 10-hydroxycamptothecin (HCPT) [27]. Here, PER2 is linked to nasopharyngeal carcinoma.