AFP and Splenomegaly: Multivariate Cox regression analysis revealed that sex (p = 0.015), splenomegaly (p = 0.002), and AFP (p = 0.035) were risk factors associated with OS in patients with PLC treated with ICIs, and that sex (p = 0.023) and splenomegaly (p = 0.013) were risk factors associated with PFS.