KEGG pathway enrichment, including “PI3K–Akt signaling pathway” involved in energy metabolism, “neuroactive ligand–receptor interaction”, “primary immunodeficiency”, “cell adhesion molecules” and “endocytosis” was performed to identify obviously changed pathways between PFF-injected TRPV1flox/flox; Cx3cr1cre mice and PFF-injected TRPV1flox/flox mice (Fig. 6g). The gene discussed is AKT1; the disease is inborn error of immunity.