Moreover, in the framework of the Collaborative Research Center 1389 (https://www.unite-glioblastoma.de), it will comprehensively assess intratumoral, microbiome-associated, proteomic and peripheral cellular determinants of response and resistance to peptide vaccine and/or ICI in patients with IDH1-mutated gliomas in an unprecedented manner. This evidence concerns the gene IDH1 and central nervous system cancer.