To summarize our findings, DKK3 interacts with proteins related to the Wnt/β-catenin pathway, such as DKK1, DKK2, WIF1, SFRP1, DVL1, AXIN1, CTNNB1, and GSK3B, and could promote cancer stemness in GBM. This evidence concerns the gene DKK2 and glioblastoma.