Compared with pNSCLC, NSCLC-BM cases were enriched for alterations in TP53, KRAS, CDKN2A, STK11, CDKN2B, NKX2-1, RB1, MYC, KEAP1, NFKBIA, SMARCA4, RICTOR, and showed decreased prevalence of PIK3CA GA. Here, SMARCA4 is linked to non-small cell lung carcinoma.