Comprehensive genomic profiling analysis of 3035 NSCLC-BM revealed that the 15 most frequently altered genes were: TP53 (77.0%, 2,337), KRAS (37.7%, 1,143), CDKN2A (32.9%, 998), STK11 (22.2%, 675), CDKN2B (21.0%, 637), EGFR (14.2%, 432), NKX2-1 (11.6%, 353), RB1 (11.4%, 347), MYC (10.6%, 323), KEAP1 (10.3%, 313), NFKBIA (9.5%, 288), SMARCA4 (9.3%, 283), NF1 (8.8%, 268), RICTOR (8.4%, 256), and PIK3CA (8.1%, 245) (Fig. 1A). This evidence concerns the gene RB1 and non-small cell lung carcinoma.