This parallels the independent and complimentary nature of PD-L1 IHC and TMB seen across multiple tumor types, including non-squamous NSCLC.30 Interestingly, the gain in mOS between the TMB high and TMB low groups, was much higher in the CD274 CN high cohort (15.6 months) compared with that in the CD274 CN low group (1.8 months). Here, CD274 is linked to neoplasm.