Based on the results of a study indicating that one-third of patients with primary refractory AML resistant to venetoclax carry TP53 mutations, some researchers noted that the integrity of the TP53 gene could be checked to determine whether acquisition of venetoclax resistance was possible in patients with initial or remitted AML to facilitate the selection of a better treatment [62]. The gene discussed is TP53; the disease is acute myeloid leukemia.