The increased MCL-1 in VEN-R AML cells also regulates pathways involved in bioenergetics and carbohydrate metabolism, including the TCA cycle, glycolysis and the pentose phosphate pathway, to change the OXPHOS level in the internal environment.[20, 84] Whether through amino acid metabolism or fatty acid metabolism, primary human LSCs rely on OXPHOS for energy, and in this cell population, OXPHOS at least partially depends on BCL-2 family proteins. Here, BCL2 is linked to acute myeloid leukemia.