Additionally, Jing et al. demonstrated that the recurrence-free survival and OS were worse in ICCs with a higher FCR compared to those with a lower FCR [12] in agreement with our findings, supporting the hypothesis that FCR is a prognostic marker for poor OS in ICC. In this study, patients with high FoxP3+ TIL count in intra-tumour of ICC have poor survival. The gene discussed is FOXP3; the disease is intrahepatic cholangiocarcinoma.