This finding is consistent with what reported for FAM83H in colorectal cancer tissues, where a nuclear staining was observed in a small population of cancer cells located at the edge of or detached from the tumor mass15, and indicates that the FAM83 family members, and likely their subcellular localization, might have a role in cell migration as previously suggest in other cancer types12,15–19,31. Here, SACK1H is linked to cancer.