Moreover, patients with low FAM83B levels tended to have a higher frequency of distant metastatization and a shorter DFS rate than those with high levels, further highlighting the correlation between dedifferentiation and low FAM83B mRNA levels, and consistent with data found in ovarian cancer8, in lung squamous cell carcinoma—SCC9, and triple-negative breast cancer20. Here, SACK1B is linked to squamous cell lung carcinoma.