We found that the knock down of FAM83B significantly affect normal and tumor thyroid cell differentiation, inducing in NTHY-ORI a reduction in the expression of the thyroid marker genes PAX8 and NIS (Fig. 6A,B), and in TPC1 cells a significant increase in the expression of the mesenchimal marker vimentin (Fig. 6C,D). The gene discussed is PAX8; the disease is neoplasm.