Our findings are interesting in the context of recent studies describing increased TLR7 and TLR9 expression in primary SjS (pSjS) patient PBMCs and parotid glands and increased detection of IL-1β and TNF secreting cells in the pSjS peripheral blood; as our data indicate ACs can drive both TLR activation and cytokine expression in our SjS model26,27. Here, TNF is linked to Schwartz-Jampel syndrome.