In papillary thyroid carcinoma (PTC), the most common form of thyroid cancer, IGFBP-5 expression is targeted by miR-204-5p [69], in contrast with the alternate precursor product, miR-204-3p, which was noted earlier as targeting IGFBP-2 in glioma [43]. This evidence concerns the gene IGFBP2 and central nervous system cancer.